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Description

Jacoby, D

- Intgr Med (Encinitas)

Specifically, sirtuins participate in multiple physiological reactions that regulate cellular metabolism through the NAD + -dependent deacetylation of target proteins including histones, such as H1, H3 and H4, transcription factors and co-activators, including p53, NF-B, peroxisome proliferator-activated receptor- co-activator-1 (PGC-1) and forkhead box O1 (FOXO1), and signalling regulators of metabolism, including protein kinase A, 5-AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) [37,38,39,40,41,42,43]